Hydrochloric Acid → HCID 178513824, 화합물

HRID 514676

반응식

HRID 514676 반응식
O.O.Cl.[OH:4][C:5]1[NH:9][CH:8]=[N:7][C:6]=1[C:10]([NH2:12])=[O:11].Cl.C([O-])=O.[Na+]>>[OH:4][C:5]1[NH:9][CH:8]=[N:7][C:6]=1[C:10]([NH2:12])=[O:11]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 2723810Sodium FormateHCID 178479550HCID 178479550, 화합물

생성물 1

HCID 178513824HCID 178513824, 화합물수율 98.9%

반응 조건

온도
50 °C

실험 절차

Under the nitrogen atmosphere, 20.0 g of 5-hydroxy-1H-imidazole-4-carboxamide hydrochloric acid salt dihydrate prepared according to the method of Reference Example 2 was added to 240 mL of 0.45 mol/L hydrochloric acid and dissolved therein by heating to 50° C. At 50° C., 40 mL aqueous solution containing 14.3 g of sodium formate was added dropwise thereto over 35 minutes. The reaction mixture was cooled and stirred for 90 minutes with the inside temperature of 5° C. The crystal was collected by filtration and then washed with a mixture liquid containing 20 mL of acetone and 40 mL of water followed by 60 mL of acetone to give 12.6 g of 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate as a pale yellow crystal.

후처리

  1. dissolutiondissolved
  2. additionwas added dropwise
  3. temperatureThe reaction mixture was cooled
  4. filtrationThe crystal was collected by filtration
  5. washwashed with a mixture liquid
  6. additioncontaining 20 mL of acetone and 40 mL of water

출처 및 근거

ORD 기록
ord-7a26519181884950b0d8142ed4d3f191
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108928B2

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