Hydrochloric Acid → HCID 178513824, 화합물

HRID 514677

반응식

HRID 514677 반응식
O.O.Cl.[OH:4][C:5]1[NH:9][CH:8]=[N:7][C:6]=1[C:10]([NH2:12])=[O:11].Cl.C([O-])=O.[Na+]>>[OH:4][C:5]1[NH:9][CH:8]=[N:7][C:6]=1[C:10]([NH2:12])=[O:11]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 2723810Sodium FormateHCID 178479550HCID 178479550, 화합물

생성물 1

HCID 178513824HCID 178513824, 화합물수율 100.5%

반응 조건

온도
50 °C

실험 절차

Under the nitrogen atmosphere, 20.0 g of 5-hydroxy-1H-imidazole-4-carboxamide hydrochloric acid salt dihydrate prepared according to the method of Reference Example 2 was added to 240 mL of 0.45 mol/L hydrochloric acid and dissolved therein by heating to 50° C. At 50° C., 40 mL aqueous solution containing 14.3 g of sodium formate was added dropwise thereto over 33 minutes. The reaction mixture was cooled. The crystal was collected by filtration and then washed with a mixture liquid containing 20 mL of acetone and 40 mL of water followed by 60 mL of acetone to give 12.8 g of 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate as a pale yellow crystal. The infrared absorption spectrum (ATR method) corresponds to that of Example 4.

후처리

  1. dissolutiondissolved
  2. additionwas added dropwise
  3. temperatureThe reaction mixture was cooled
  4. filtrationThe crystal was collected by filtration
  5. washwashed with a mixture liquid
  6. additioncontaining 20 mL of acetone and 40 mL of water

출처 및 근거

ORD 기록
ord-46b3f5b3dd64454bb4070a247dba9925
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108928B2

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