Hydrochloric Acid → 3-[(Propan-2-ylsulfonyl)methyl]anilinium chloride

HRID 514704노트

반응식

HRID 514704 반응식
[CH3:1][CH:2]([S:4]([CH2:7][C:8]1[CH:9]=[C:10]([NH:14]C(=O)C)[CH:11]=[CH:12][CH:13]=1)(=[O:6])=[O:5])[CH3:3].[ClH:18].C(O)C.C(OCC)(=O)C>C(O)C>[Cl-:18].[CH3:3][CH:2]([S:4]([CH2:7][C:8]1[CH:9]=[C:10]([CH:11]=[CH:12][CH:13]=1)[NH3+:14])(=[O:6])=[O:5])[CH3:1]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 21584252Ethanol ethylacetateHCID 70976422N-{3-[(Propan-2-ylsulfonyl)methyl]phenyl}acetamide

생성물 1

HCID 867296113-[(Propan-2-ylsulfonyl)methyl]anilinium chloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of N-{3-[(propan-2-ylsulfonyl)methyl]phenyl}acetamide (5.4 g) in ethanol (29.6 mL) was treated with concentrated hydrochloric acid (35.5 mL) and refluxed for 24 hours. The reaction mixture was condensed to dryness. The title compound (3.5 g) was obtained by crystallization from ethanol/ethyl acetate.

후처리

  1. temperaturerefluxed for 24 hours
  2. customcondensed to dryness

출처 및 근거

ORD 기록
ord-dea0212918ad4166a6a1d503b0117750
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108926B2

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