Stannous chloride dihydrate → 3-(2-Aminophenoxy)benzonitrile
반응식
[N+:1]([C:4]1[CH:18]=[CH:17][CH:16]=[CH:15][C:5]=1[O:6][C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][CH:14]=1)[C:10]#[N:11])([O-])=O.O.O.Cl[Sn]Cl>CCO>[NH2:1][C:4]1[CH:18]=[CH:17][CH:16]=[CH:15][C:5]=1[O:6][C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][CH:14]=1)[C:10]#[N:11]참가 물질
4
실험 절차
A solution of 3-(2-nitrophenoxy)benzonitrile (1.21 g, 5 mmol, 1.0 equiv) in 30 mL of EtOH was treated with SnCl2.2H2O (3.38 g, 3 equiv) at reflux for 4 h. The volatile was evaporated and the residue was redissolved in EtOAc, washed with saturated aqueous NaHCO3 and 1N NaOH. The organic layer was dried over MgSO4, filtered and evaporated to give 3-(2-aminophenoxy)benzonitrile (1.04 g, 99%). MS found for C13H11N2O (M+H)+: 211.
후처리
- temperatureat reflux for 4 h
- customThe volatile was evaporated
- dissolutionthe residue was redissolved in EtOAc
- washwashed with saturated aqueous NaHCO3 and 1N NaOH
- dry with materialThe organic layer was dried over MgSO4
- filtrationfiltered
- customevaporated
출처 및 근거
- ORD 기록
- ord-c9d7f97e42fd482ea06a7b38847420cf
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09108922B2
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