D-Tartaric acid → HCID 67054630, 화합물

HRID 515069

반응식

HRID 515069 반응식
[CH3:1][C@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C@H:8]1[CH2:10][C@@H:9]1[C:11]1[CH:16]=[CH:15][C:14]([N:17]2[C:22](=[O:23])[CH:21]=[CH:20][CH:19]=[N:18]2)=[CH:13][CH:12]=1.[C:24]([OH:33])(=[O:32])[C@H:25]([C@@H:27]([C:29]([OH:31])=[O:30])[OH:28])[OH:26]>CO>[OH:28][C@@H:27]([C@H:25]([OH:26])[C:24]([OH:33])=[O:32])[C:29]([OH:31])=[O:30].[CH3:1][C@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C@H:8]1[CH2:10][C@@H:9]1[C:11]1[CH:16]=[CH:15][C:14]([N:17]2[C:22](=[O:23])[CH:21]=[CH:20][CH:19]=[N:18]2)=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 439655D-Tartaric acidHCID 236359352-(4-((1S,2S)-2-(((S)-2-methylpyrrolidin-1-yl)methyl)cyclopropyl)phenyl)pyridazin-3(2H)-one

생성물 1

HCID 67054630HCID 67054630, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of the product from the Example 34G, 2-(4-((1S,2S)-2-(((S)-2-methylpyrrolidin-1-yl)methyl)cyclopropyl)phenyl)pyridazin-3(2H)-one, (615 mg, 0.5 mmol) in methanol (10 mL) was treated with D-tartaric acid (350 mg) and stirred at ambient temperature for 30 minutes. The mixture was concentrated under the reduced pressure and the residue was crystallized in 2-propanol/acetone to provide the title product as white crystalline solid. M.P. 145-147.1° C. Anal. Calc. for C23H26N2.C4H6O6: C, 60.12; H, 6.36; N, 9.14. Found: C, 59.94; H, 6.57; N, 9.17.

후처리

  1. concentrationThe mixture was concentrated under the reduced pressure
  2. customthe residue was crystallized in 2-propanol/acetone

출처 및 근거

ORD 기록
ord-570057a922664e928bbd667208df0566
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108948B2

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