Sodium Hydroxide → 4-(3-(Cyclopropylmethyl)ureido)benzoic acid

HRID 515325노트

반응식

HRID 515325 반응식
[CH:1]1([CH2:4][NH:5][C:6](=[O:19])[NH:7][C:8]2[CH:18]=[CH:17][C:11]([C:12]([O:14]CC)=[O:13])=[CH:10][CH:9]=2)[CH2:3][CH2:2]1.[OH-].[Na+]>C(O)C>[CH:1]1([CH2:4][NH:5][C:6](=[O:19])[NH:7][C:8]2[CH:9]=[CH:10][C:11]([C:12]([OH:14])=[O:13])=[CH:17][CH:18]=2)[CH2:2][CH2:3]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 3830959Ethyl 4-(3-(cyclopropylmethyl)ureido)benzoate

생성물 1

HCID 580558194-(3-(Cyclopropylmethyl)ureido)benzoic acid수율 93.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl 4-(3-(cyclopropylmethyl)ureido)benzoate (55.3 mmol, 14.5 g) was suspended in ethanol (400 mL) and 4M sodium hydroxide (332 mmol, 83 mL) added. The reaction was then refluxed until complete saponification was achieved. The ethanol was removed by evaporation and the reaction neutralised with concentrated hydrochloric acid. The white precipitate was collected and washed with water. The material was dried under vacuum to give the title compound (12.1 g).

후처리

  1. temperatureThe reaction was then refluxed until complete saponification
  2. customThe ethanol was removed by evaporation
  3. customthe reaction neutralised with concentrated hydrochloric acid
  4. customThe white precipitate was collected
  5. washwashed with water
  6. customThe material was dried under vacuum

출처 및 근거

ORD 기록
ord-c504d9ca6e2f4b2bb229cc65251b51d4
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108939B2

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