3-Phenoxytoluene → 1-Bromo-2-methyl-4-phenoxybenzene

HRID 51535

반응식

HRID 51535 반응식
[O:1]([C:8]1[CH:9]=[C:10]([CH3:14])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:15]N1C(=O)CCC1=O>C(#N)C>[C:2]1([O:1][C:8]2[CH:13]=[CH:12][C:11]([Br:15])=[C:10]([CH3:14])[CH:9]=2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 191653-PhenoxytolueneHCID 67184N-bromobutanimide

생성물 1

HCID 128585521-Bromo-2-methyl-4-phenoxybenzene수율 97.8%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 3-phenoxytoluene (2.5 g, 0.0136 mol) and N-bromosuccinimide (2.54 g, 0.0142 mol) was stirred in acetonitrile (20 mL) for 2.5 hours under an atmosphere of nitrogen. The solvent was removed under reduced pressure. Carbon tetrachloride was added to the residue and the resulting solid was removed by filtration. The filtrate was concentrated to yield 4-bromo-3-methylphenyl phenyl ether as yellow oil (3.5 g, 0.0133 mol):

후처리

  1. customThe solvent was removed under reduced pressure
  2. additionCarbon tetrachloride was added to the residue
  3. customthe resulting solid was removed by filtration
  4. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-41372e57b62d4ee7b9f74314c3d1de09
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713474B2

연결된 노트

불러오는 중…