Trimethyl orthoformate → HCID 89501076, 화합물

HRID 515760노트

반응식

HRID 515760 반응식
[Cl:1][C:2]1[C:8]([F:9])=[CH:7][C:5]([NH2:6])=[C:4]([I:10])[CH:3]=1.[N-:11]=[N+:12]=[N-:13].[Na+].[CH:15](OC)(OC)OC>CC(O)=O>[Cl:1][C:2]1[C:8]([F:9])=[CH:7][C:5]([N:6]2[CH:15]=[N:13][N:12]=[N:11]2)=[C:4]([I:10])[CH:3]=1

참가 물질

5

반응물 3

HCID 9005Trimethyl orthoformateHCID 33557Sodium AzideHCID 575389634-Chloro-5-fluoro-2-iodoaniline

생성물 1

HCID 89501076HCID 89501076, 화합물수율 872.9%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To Intermediate 5A (47 g, 17.3 mmol) in AcOH (470 mL) was added NaN3 (33.76 g, 51.9 mmol) and trimethyl orthoformate (56.8 mL, 51.9 mmol). After 30 h, the reaction was poured into ice water, then solid was filtered-off and washed with petroleum ether to afford 49 g of Intermediate 5B. MS (ESI) m/z: 324.8 (M+H)+.

후처리

  1. washwashed with petroleum ether

출처 및 근거

ORD 기록
ord-24f0ea663c26440e804d9b5d0c648cee
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108951B2

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