Diisopropylethylamine → HCID 117830954, 화합물

HRID 515928노트

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HRID 515928 반응식
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([C:7]([OH:9])=O)=[C:3]1[CH3:10].ClC(N(C)C)=C(C)C.[CH2:19]([O:26][C:27]1[CH:34]=[CH:33][C:30]([NH:31][CH3:32])=[CH:29][CH:28]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(N(C(C)C)C(C)C)C>ClCCCl.ClCCl>[CH2:19]([O:26][C:27]1[CH:28]=[CH:29][C:30]([N:31]([CH3:32])[C:7]([C:4]2[CH:5]=[CH:6][N:2]([CH3:1])[C:3]=2[CH3:10])=[O:9])=[CH:33][CH:34]=1)[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

참가 물질

7

반응물 4

HCID 81531DiisopropylethylamineHCID 6407921-Chloro-N,N-2-trimethylpropenylamineHCID 162176454-(Benzyloxy)-N-methylanilineHCID 225617641,2-dimethyl-1H-pyrrole-3-carboxylic acid

생성물 1

HCID 117830954HCID 117830954, 화합물

시약·촉매·용매 2

HCID 111,2-Dichloroethane용매2회HCID 6344Dichloromethane용매

실험 절차

To a suspension of 1,2-dimethylpyrrole-3-carboxylic acid (2.085 g; 15 mmol) in 1,2-dichloroethane (40 mL) there is added 1-chloro-N,N,2-trimethyl-prop-1-en-1-amine (2.37 mL; 17.9 mmol), and the solution formed is stirred for 1 hour. To the resulting solution there is added, dropwise, an ice-cold solution of 4-benzyloxy-N-methyl-aniline (3.73 g; 15 mmol) and N-ethyl-N-isopropyl-propan-2-amine (7.75 mL; 45 mmol) in 1,2-dichloroethane (40 mL). The reaction mixture is stirred at ambient temperature for 1 hour; it is then diluted with dichloromethane (250 mL) and washed with water (2×30 mL), dried over Na2SO4 and evaporated. The crude product is triturated with diethyl ether and the solid formed is filtered off to yield the title compound.

후처리

  1. customthe solution formed
  2. additionTo the resulting solution there is added
  3. stirringThe reaction mixture is stirred at ambient temperature for 1 hour
  4. washwashed with water (2×30 mL)
  5. dry with materialdried over Na2SO4
  6. customevaporated
  7. customThe crude product is triturated with diethyl ether
  8. customthe solid formed
  9. filtrationis filtered off

출처 및 근거

ORD 기록
ord-33abba4a03ed46dabb45d2584086f89f
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108983B2

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