Cysteamine Hydrochloride → HCID 22253943, 화합물

A solution of cysteamine hydrochloride (30.81 mmol) in pivaloyl chloride (10 mL) was heated to 100° C. during 15 minutes. The reaction mixture was allowed to cool down to room temperature and was triturated in Et2O. The mixture was filtered. The solid was washed with Et2O and then dissolved in DMF (50 mL and 5 drops of HCl) upon heating. After cooled down to room temperature, the mixture was precipitated with Et2O, filtered and washed with Et2O to give after drying under vacuum the expected compound as a white solid in 94% yield. 1H NMR (DMSO-d6, 400 MHz) δ (ppm) 1.19 (s, 9H), 2.88 (t, J=7.08 Hz, 2H), 3.05-3.08 (m, 2H), 8.30 (s, 3H).

1. customwas triturated in Et2O
2. filtrationThe mixture was filtered
3. washThe solid was washed with Et2O
4. dissolutiondissolved in DMF (50 mL and 5 drops of HCl)
5. temperatureupon heating
6. temperatureAfter cooled down to room temperature
7. customthe mixture was precipitated with Et2O
8. filtrationfiltered
9. washwashed with Et2O
10. customto give
11. dry with materialafter drying under vacuum the expected compound as a white solid in 94% yield

ORD 기록

ord-4dadf182d78d4490bd7b5fb27108eeac

출처 데이터셋

uspto-grants-2015_08

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US09109001B2