Triphenylphosphine → tert-butyl 4-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-piperidinecarboxylate

HRID 51614

반응식

HRID 51614 반응식
[Cl:1][C:2]1[C:3]2[C:10]([I:11])=[CH:9][NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.O[CH:13]1[CH2:18][CH2:17][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:15][CH2:14]1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CCOC(/N=N/C(OCC)=O)=O>O1CCCC1>[Cl:1][C:2]1[C:3]2[C:10]([I:11])=[CH:9][N:8]([CH:13]3[CH2:18][CH2:17][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:15][CH2:14]3)[C:4]=2[N:5]=[CH:6][N:7]=1

참가 물질

6

반응물 4

HCID 11776TriphenylphosphineHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 5462977Diethyl azodicarboxylateHCID 148092816-Chloro-7-iodo-7-deazapurine

생성물 1

HCID 22736256tert-butyl 4-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-piperidinecarboxylate수율 47.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (6.48 g, 21.78 mmol) in tetrahydrofuran (200 mL) at 0° C. under a nitrogen atmosphere was treated with tert-butyl 4-hydroxy-1-piperidinecarboxylate (13.147 g, 65.33 mmol) and triphenylphosphine (11.43 g, 43.56 mmol) and stirred for 30 minutes. Diethylazodicarboxyate (7.61 g, 43.56 mmol) was added drop-wise over 15 minutes to the reaction solution. The ice bath was removed after 15 minutes, and the reaction mixture was allowed to stir over night. The solvent was evaporated under reduced pressure, and then the yellow gummy solid dissolved in dichloromethane. The solid precipitated was filtered and discarded. The filtrate was evaporated under reduced pressure. Recrystallization from ethyl acetate/heptane yielded 4.82 g (47%) of tert-butyl 4-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-piperidinecarboxylate. 1H NMR (DMSO-d6, 400 MHz) 8.64(s, 1H), 8.20 (s, 1H), 4.89-4.84(m, 1H), 4.13-4.10 (m, 2H), 3.00-2.80(br s, 2H), 2.01-1.88 (m, 4H), 1.43(s, 9H). Waters 2690 Alliance HPLC (Symmetry Shield RP18 3.5 m, 2.1×50 mm; 5%-95% acetonitrile-0.1 M ammonium acetate over 15 min, 0.5 mL/min) Rt 7.825 minutes.

후처리

  1. customThe ice bath was removed after 15 minutes
  2. stirringto stir over night
  3. customThe solvent was evaporated under reduced pressure
  4. dissolutionthe yellow gummy solid dissolved in dichloromethane
  5. customThe solid precipitated
  6. filtrationwas filtered
  7. customThe filtrate was evaporated under reduced pressure
  8. customRecrystallization from ethyl acetate/heptane

출처 및 근거

ORD 기록
ord-16c14667cb0d4275929f86d61c359cd9
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713474B2

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