1,2-Ethanediamine, N1,N1,N2-trimethyl- → (2S,4S)-1-acryloyl-4-(4-amino-5-((3,5-dimethoxyphenyl)ethynyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-N-(2-(dimethylamino)ethyl)-N-methylpyrrolidine-2-carboxamide

반응식

[NH2:1][C:2]1[C:3]2[C:10]([C:11]#[C:12][C:13]3[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[C:15]([O:21][CH3:22])[CH:14]=3)=[CH:9][N:8]([C@@H:23]3[CH2:27][N:26]([C:28](OC(C)(C)C)=[O:29])[C@H:25]([C:35](O)=[O:36])[CH2:24]3)[C:4]=2[N:5]=[CH:6][N:7]=1.CN(C(ON1N=N[C:48]2C=CC=C[C:47]1=2)=[N+](C)C)C.[B-](F)(F)(F)F.[CH3:60][N:61]([CH3:66])[CH2:62][CH2:63][NH:64][CH3:65].CCN(C(C)C)C(C)C>C(#N)C.O.C(OCC)(=O)C>[C:28]([N:26]1[CH2:27][C@@H:23]([N:8]2[C:4]3[N:5]=[CH:6][N:7]=[C:2]([NH2:1])[C:3]=3[C:10]([C:11]#[C:12][C:13]3[CH:14]=[C:15]([O:21][CH3:22])[CH:16]=[C:17]([O:19][CH3:20])[CH:18]=3)=[CH:9]2)[CH2:24][C@H:25]1[C:35]([N:64]([CH2:63][CH2:62][N:61]([CH3:66])[CH3:60])[CH3:65])=[O:36])(=[O:29])[CH:47]=[CH2:48]