Hydrochloric Acid → 4-(10-Allyloxydecyloxy)benzoic acid

HRID 5163

반응식

HRID 5163 반응식
[CH2:1]([O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]I)[CH:2]=[CH2:3].C[O:17][C:18]([C:20]1[CH:21]=[CH:22][C:23]([OH:26])=[CH:24][CH:25]=1)=[O:19].C(=O)([O-])[O-].[K+].[K+].[OH-].[K+].Cl>C(O)C>[CH2:1]([O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:26][C:23]1[CH:24]=[CH:25][C:20]([C:18]([OH:19])=[O:17])=[CH:21][CH:22]=1)[CH:2]=[CH2:3]

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 7456MethylparabenHCID 11430Potassium CarbonateHCID 14797Potassium HydroxideHCID 1979791310-Iododecyl allyl ether

생성물 1

HCID 197979084-(10-Allyloxydecyloxy)benzoic acid수율 80%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

70 mmol (22.7 g) of 10-iododecyl allyl ether, 70 mmol (10.6 g) of methyl p-hydroxybenzoate, and 70 mmol (9.6 g) of potassium carbonate were refluxed in absolute ethanol for 15 hours. After addition of an aqueous potassium hydroxide solution (containing 4.0 g of potassium hydroxide) into the reaction solution, the resulting mixture was further heated at 80° C. for 5 hours. After conclusion of the reaction, the reaction solution was acidified with hydrochloric acid, and the acidified reaction solution was then concentrated under reduced pressure. Water was added to the residue to form a suspension, and the insoluble matter was collected and was then dried, to obtain 18.7 g of 4-(10-allyloxydecyloxy)benzoic acid (Yield: 80%).

후처리

  1. customAfter conclusion of the reaction
  2. customthe acidified reaction solution
  3. concentrationwas then concentrated under reduced pressure
  4. additionWater was added to the residue
  5. customto form a suspension
  6. customthe insoluble matter was collected
  7. customwas then dried

출처 및 근거

ORD 기록
ord-259cdfd8194a46da8519bc2b1b2c0ec8
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05243065

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