Lithium Hydroxide → 5-(2,2,3,3,3-Pentafluoro-propoxy)-pyridine-2-carboxylic acid

반응식

C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]([F:19])([F:18])[C:14]([F:17])([F:16])[F:15])=[CH:7][N:6]=1)=[O:4].[OH-].[Li+]>>[F:19][C:13]([F:18])([C:14]([F:15])([F:16])[F:17])[CH2:12][O:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[N:6][CH:7]=1

참가 물질

반응물 2

HCID 3939Lithium Hydroxide

HCID 574758785-(2,2,3,3,3-Pentafluoro-propoxy)-pyridine-2-carboxylic acid methyl ester

생성물 1

HCID 574758775-(2,2,3,3,3-Pentafluoro-propoxy)-pyridine-2-carboxylic acid

실험 절차

In a manner analogous to that described in example 17b), the hydrolysis of the 5-(2,2,3,3,3-pentafluoro-propoxy)-pyridine-2-carboxylic acid methyl ester with lithium hydroxide yielded the 5-(2,2,3,3,3-pentafluoro-propoxy)-pyridine-2-carboxylic acid as a white solid. MS (ISP): m/z=271 [M+H]+.

출처 및 근거

ORD 기록: ord-18647791ec21496b99061747a252763d
출처 데이터셋: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09115098B2

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