Water → 4-[(2-Methylquinolin-4-yl)methoxy]benzoic acid

HRID 517521노트

반응식

HRID 517521 반응식
[OH-].[Na+].O.[CH3:4][C:5]1[CH:14]=[C:13]([CH2:15][O:16][C:17]2[CH:32]=[CH:31][C:20]([C:21]([O:23]CC3C=CC=CC=3)=[O:22])=[CH:19][CH:18]=2)[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=1>O1CCCC1.CO>[CH3:4][C:5]1[CH:14]=[C:13]([CH2:15][O:16][C:17]2[CH:32]=[CH:31][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=2)[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=1

참가 물질

6

반응물 3

HCID 962WaterHCID 14798Sodium Hydroxide2회HCID 67056944HCID 67056944, 화합물

생성물 1

HCID 220327754-[(2-Methylquinolin-4-yl)methoxy]benzoic acid수율 81%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

2.3 ml (18.6 mmol) of an 8N aqueous solution of sodium hydroxide and 5 ml of water are added to a solution of 3.6 g (9.3 mmol) of benzyl 4-(2-methylquinolin-4-ylmethoxy)benzoate diluted in 20 ml of tetrahydrofuran and 30 ml of methanol. The reaction medium is stirred at ambient temperature for 48 h then 1 ml of an 8N aqueous solution of sodium hydroxide is added and the mixture is heated at 70° C. for 5 h. After evaporation of the tetrahydrofuran, water and a 1N aqueous solution of acetic acid are added. The suspension is stirred overnight at ambient temperature then filtered. The solid obtained is dried under vacuum at 40° C. for 6 h. 2.2 g (81%) of 4-(2-methylquinolin-4-ylmethoxy)benzoic acid are obtained in the form of a white solid.

후처리

  1. temperaturethe mixture is heated at 70° C. for 5 h
  2. customAfter evaporation of the tetrahydrofuran, water
  3. additiona 1N aqueous solution of acetic acid are added
  4. stirringThe suspension is stirred overnight at ambient temperature
  5. filtrationthen filtered
  6. customThe solid obtained
  7. customis dried under vacuum at 40° C. for 6 h

출처 및 근거

ORD 기록
ord-f7c789ba8bf442a9ae870cd428d7e24d
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09115102B2

반응 노트

불러오는 중…