Sodium Bromide → 3-Bromo-1-(3-bromophenyl)butan-2-one

HRID 517551노트

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HRID 517551 반응식
[Na+].[Br-:2].[Br:3][C:4]1[CH:5]=[C:6]([CH2:10][C:11](=[O:15])[CH:12](Cl)[CH3:13])[CH:7]=[CH:8][CH:9]=1>CC(C)=O.CCCCCC>[Br:2][CH:12]([CH3:13])[C:11](=[O:15])[CH2:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([Br:3])[CH:5]=1

참가 물질

5

반응물 2

HCID 253881Sodium BromideHCID 867114911-(3-Bromophenyl)-3-chlorobutan-2-one

생성물 1

HCID 867114923-Bromo-1-(3-bromophenyl)butan-2-one

시약·촉매·용매 2

HCID 180Acetone용매HCID 8058Hexane용매

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온도
70 °C

실험 절차

A mixture of NaBr (197 mg, 1.9 mmol) and 1-(3-bromophenyl)-3-chlorobutan-2-one (100 mg, 0.38 mmol) in acetone (2 ml) was stirred at 70° C. for 3 h. The mixture was diluted with hexane and filtered to remove the solid. The solvent was removed under reduced pressure and the residue was used for the next step without further purification. MS (ES+) C10H10Br2O requires: 303, 305 found: 304, 306 [M+H]+(1:1).

후처리

  1. filtrationfiltered
  2. customto remove the solid
  3. customThe solvent was removed under reduced pressure
  4. customthe residue was used for the next step without further purification

출처 및 근거

ORD 기록
ord-8d51c3e1bfe7421f991cd64aee8c6583
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09115120B2

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