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Formaldehyde → 1,1-Dimethylethyl 2,2-dimethyl-4-({1-[4-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-1-piperazinecarboxylate

HRID 517705
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HRID 517705 반응식
[CH2:1]=O.[CH3:3][C:4]1([CH3:17])[CH2:9][NH:8][CH2:7][CH2:6][N:5]1[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11].[F:18][C:19]([F:29])([F:28])[C:20]1[CH:25]=[CH:24][C:23]([N+:26]#[C-:27])=[CH:22][CH:21]=1.C[Si]([N:34]=[N+:35]=[N-:36])(C)C>CO>[CH3:3][C:4]1([CH3:17])[CH2:9][N:8]([CH2:1][C:27]2[N:26]([C:23]3[CH:22]=[CH:21][C:20]([C:19]([F:28])([F:29])[F:18])=[CH:25][CH:24]=3)[N:36]=[N:35][N:34]=2)[CH2:7][CH2:6][N:5]1[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 712FormaldehydeHCID 78378AzidotrimethylsilaneHCID 27594124-(Trifluoromethyl)phenyl isocyanideHCID 299224001,1-Dimethylethyl 2,2-dimethyl-1-piperazinecarboxylate

생성물 1

HCID 680745071,1-Dimethylethyl 2,2-dimethyl-4-({1-[4-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-1-piperazinecarboxylate

시약·촉매·용매 1

HCID 887
Methanol
용매

실험 절차

To a solution of formaldehyde (0.044 mL, 0.584 mmol) in methanol (2 mL) was added 1,1-dimethylethyl 2,2-dimethyl-1-piperazinecarboxylate (125 mg, 0.584 mmol, commercially available, for example from ChemPacific Corp., Baltimore, USA). The reaction mixture was stirred at room temperature for 1 hour before the addition of 4-(trifluoromethyl)phenylisocyanide (100 mg, 0.584 mmol, Fluorochem, Old Glossop, UK) and trimethylsilyl azide (0.092 mL, 0.701 mmol). The resulting reaction mixture was stirred at room overnight.

후처리

  1. customThe resulting reaction mixture

출처 및 근거

ORD 기록
ord-5ddbe548ed5448e39e250f8764c6066a
출처 데이터셋
uspto-grants-2015_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09115132B2

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