Water → ethyl 6-bromo-2-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate
반응식
[CH3:1][C:2]1[S:9][C:8]2[CH:7]=[C:6]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[NH:5][C:4]=2[CH:3]=1.[Br:15]N1C(=O)CCC1=O.O>O1CCCC1>[Br:15][C:7]1[C:8]2[S:9][C:2]([CH3:1])=[CH:3][C:4]=2[NH:5][C:6]=1[C:10]([O:12][CH2:13][CH3:14])=[O:11]참가 물질
5
실험 절차
To a solution of ethyl 2-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate (1.0 g) in tetrahydrofuran (10 mL) was added N-Bromosuccinimide (0.94 g) under ice-cooling, and the mixture was stirred at the same temperature for 1 hour. To the reaction mixture was added water and the resulting mixture was extracted with ethyl acetate. The organic layer was concentrated under reduced pressure. The obtained residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate=97/3−76/24) to give the title compound (0.96 g).
후처리
- temperaturecooling
- extractionthe resulting mixture was extracted with ethyl acetate
- concentrationThe organic layer was concentrated under reduced pressure
- customThe obtained residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate=97/3−76/24)
출처 및 근거
- ORD 기록
- ord-d7dfb078f25547c38e55d5827a6a83b6
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09115144B2
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