Sodium Thiosulfate → 2-Bromo-4-(ethylsulfonyl)-1-fluorobenzene

HRID 518300노트

반응식

HRID 518300 반응식
[Br:1][C:2]1[CH:7]=[C:6](SCC)[CH:5]=[CH:4][C:3]=1[F:11].[CH:12]1C=C(Cl)C=C(C(OO)=O)[CH:13]=1.[O-:23][S:24]([O-:27])(=S)=O.[Na+].[Na+]>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[C:6]([S:24]([CH2:12][CH3:13])(=[O:27])=[O:23])[CH:5]=[CH:4][C:3]=1[F:11]

참가 물질

5

반응물 3

HCID 24477Sodium ThiosulfateHCID 70297m-Chloroperbenzoic acidHCID 86704956(3-Bromo-4-fluorophenyl)(ethyl)sulfane

생성물 1

HCID 585219752-Bromo-4-(ethylsulfonyl)-1-fluorobenzene수율 50%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To 2-bromo-4-ethylsulfanyl-1-fluorobenzene (2.2 g, 9.36 mmol) in DCM (20 mL) was added m-CPBA (6.47 g, 37.4 mmol). The mixture was stirred at room temperature for 12 h. Aqueous saturated Na2S2O3 (100 mL) was added, and extractive work up with CH2Cl2 gave the title compound (1.5 g, 50%) as a yellow solid which was carried on without purification. 1H NMR (CDCl3, 400 MHz) δ 8.15 (dd, J1=6.4 Hz, J2=2.4 Hz, 1H), 7.88-7.85 (m, 1H), 7.32 (t, J=8.4 Hz, 1H), 3.14 (q, J=7.2 Hz, 2H), 1.31 (t, J=7.6 Hz, 3H).

출처 및 근거

ORD 기록
ord-c8d210d2c33f4505a36f586e6ce4a014
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09115114B2

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