Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → HCID 178457841, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 2-(4-Piperidyl)-2-propanol | HCID 5200321 | — |
| 반응물 | HCID 178457831 | HCID 178457831 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | Ammonium Hydroxide | HCID 14923 | — |
| 생성물 | HCID 178457841 | HCID 178457841 | 200.2% |
반응 단계
A suspension of cis-4-(2-chloro-5-nitropyridin-4-ylamino)-N-isopropylcyclohexanecarboxamide (0.200 g, 0.587 mmol) and 2-(piperidin-4-yl)propan-2-ol (0.420 g, 2.93 mmol) in 2-propanol (2.003 mL) was microwave irradiated for 1 hour at 150° C. The reaction mixture was concentrated in vacuo, and the residual material was purified via silica gel chromatography eluting with isocratic 90:10:1 DCM:MeOH:NH4OH, to provide cis-4-(2-(4-(2-hydroxypropan-2-yl)piperidin-1-yl)-5-nitropyridin-4-ylamino)-N-isopropylcyclohexanecarboxamide as a yellow solid (0.263 g, 100% yield). MS m/z=448.2 [M+H], calc 447.57 for C23H37FN5O4.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09115127B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-b165d5af108c47a4a6a00fd7e4de35a5 |
| 출처 메모 | uspto-grants-2015_08 |