Hydrochloric Acid → 2,2,2-Trifluoro-1-(piperidin-4-yl)ethan-1-ol hydrochloride
반응식
[F:1][C:2]([F:23])([F:22])[CH:3]([CH:9]1[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1)[O:4][Si](C)(C)C.[ClH:24].CCOCC>C(Cl)Cl.CO>[ClH:24].[F:23][C:2]([F:1])([F:22])[CH:3]([CH:9]1[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]1)[OH:4]참가 물질
6
실험 절차
To a solution of tert-butyl 4-(2,2,2-trifluoro-1-(trimethylsilyloxy)ethyl)piperidine-1-carboxylate (1.6 g, 4.50 mmol) in DCM (9 mL) and MeOH (1 mL) was added 2 M HCl in ether (11.25 mL, 22.51 mmol). The reaction was stirred at RT for 16 hours. The precipitate that formed was collected by vacuum filtration, washed with diethyl ether, and dried in vacuo to generate 2,2,2-trifluoro-1-(piperidin-4-yl)ethanol hydrochloride as a white powder (0.83 g, 84% yield).
후처리
- customThe precipitate that formed
- filtrationwas collected by vacuum filtration
- washwashed with diethyl ether
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-3e9fe27fbeb64672a506e9f4da0f6a78
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09115127B2
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