Hydrochloric Acid → 2-(Azetidin-3-yl)propan-2-ol hydrochloride
반응식
[OH:1][C:2]([CH:5]1[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1)([CH3:4])[CH3:3].[ClH:16].O1CCOCC1>C(Cl)Cl>[ClH:16].[NH:7]1[CH2:8][CH:5]([C:2]([OH:1])([CH3:4])[CH3:3])[CH2:6]1참가 물질
5
실험 절차
To a solution of tert-butyl 3-(2-hydroxypropan-2-yl)azetidine-1-carboxylate (0.87 g, 4.04 mmol) in DCM (15 mL) at 0° C. was added 4 M HCl in dioxane (8.08 mL, 16.16 mmol) dropwise. The reaction was stirred overnight at RT. The reaction mixture was concentrated and dried in vacuo to generate 2-(azetidin-3-yl)propan-2-ol hydrochloride as a brown solid (0.44 g, 71.8% yield).
후처리
- concentrationThe reaction mixture was concentrated
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-44cd91c7a6ef45918a21832f7c7fd2b5
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09115127B2
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