Hydrochloric Acid → HCID 66728668, 화합물
반응식
[F:1][C:2]([F:20])([F:19])[CH2:3][NH:4][CH2:5][CH:6]1[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]1.[ClH:21].O1CCOCC1>C(Cl)Cl>[ClH:21].[ClH:21].[F:20][C:2]([F:1])([F:19])[CH2:3][NH:4][CH2:5][CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1참가 물질
5
실험 절차
To a solution of tert-butyl 4-((2,2,2-trifluoroethylamino)methyl)piperidine-1-carboxylate (1.49 g, 5.03 mmol) in DCM (25 mL) was added 4 N HCl in dioxane (5.03 mL, 20.11 mmol). The reaction was stirred at RT. After 16 hours, the white precipitate was collected by vacuum filtration, washed with diethyl ether, and dried in vacuo, to generate 2,2,2-trifluoro-N-(piperidin-4-ylmethyl)ethanamine dihydrochloride as a white powder (1.07 g, 3.98 mmol, 79% yield).
후처리
- filtrationthe white precipitate was collected by vacuum filtration
- washwashed with diethyl ether
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-5fe878d7a94946e99177089a9847a72f
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09115127B2
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