Methyl iodide → 1-Methyl-4-[4-nitro-3-(propan-2-yloxy)phenyl]pyridinium iodide

HRID 518795

반응식

HRID 518795 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)=[CH:6][C:5]=1[O:16][CH:17]([CH3:19])[CH3:18])([O-:3])=[O:2].[CH3:20][I:21]>C(#N)C>[I-:21].[CH3:20][N+:13]1[CH:12]=[CH:11][C:10]([C:7]2[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[C:5]([O:16][CH:17]([CH3:19])[CH3:18])[CH:6]=2)=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 6328Methyl iodide2회HCID 86697963HCID 86697963, 화합물

생성물 1

HCID 866979641-Methyl-4-[4-nitro-3-(propan-2-yloxy)phenyl]pyridinium iodide수율 97.5%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
50 °C

실험 절차

A mixture of 7.35 g of 4-[4-nitro-3-(propan-2-yloxy)phenyl]pyridine and 16.1 g of methyl iodide in 150 ml of acetonitrile is heated at 50° C. (bath) for 1 h. 2.5 ml of methyl iodide are added and the heating is continued for 1 h 50. The mixture is then concentrated under vacuum, so as to obtain 11.1 g of 1-methyl-4-[4-nitro-3-(propan-2-yloxy)phenyl]pyridinium iodide.

후처리

  1. concentrationThe mixture is then concentrated under vacuum

출처 및 근거

ORD 기록
ord-e5d5d827fe6f4e26aa166d1f9bf8104c
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09115140B2

연결된 노트

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