반응식
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[C:6]([NH:13][CH3:14])=[CH:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:21][O:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27]Cl)=[CH:25][CH:24]=1.[Br:31][C:32]1[CH:33]=[C:34]([CH:38]=[CH:39][N:40]=1)[C:35](O)=[O:36].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)C(C)C)C>CN(C=O)C.C1COCC1>[Br:31][C:32]1[CH:33]=[C:34]([CH:38]=[CH:39][N:40]=1)[C:35]([NH:12][C:10]1[S:11][C:7]2[C:6]([N:13]([CH2:27][C:26]3[CH:29]=[CH:30][C:23]([O:22][CH3:21])=[CH:24][CH:25]=3)[CH3:14])=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:8]=2[N:9]=1)=[O:36]참가 물질
9
반응물 6
HCID 11430Potassium Carbonate
HCID 699934-Methyloxybenzyl chloride
HCID 81531Diisopropylethylamine
HCID 2227012-Bromoisonicotinic acid
HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)
HCID 227369784-methoxy-N7-methyl-benzothiazole-2,7-diamine생성물 1
시약·촉매·용매 2
실험 절차
From 4-methoxy-N7-methyl-benzothiazole-2,7-diamine with potassium carbonate and 4-methoxybenzyl chloride in DMF, then treatment with 2-bromo-isonicotinic acid, HATU and N-ethyldiisopropylamine in THF. ES-MS m/e (%): 515 (M{81Br}+H+, 100), 513 (M{79Br}+H+, 81).
출처 및 근거
- ORD 기록
- ord-8aa228de6d89408993c0959d3705b3f0
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06713499B2
연결된 노트
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