반응식
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[C:6]([NH:13][CH3:14])=[CH:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:21](Br)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[Br:29][C:30]1[CH:31]=[C:32]([CH:36]=[CH:37][N:38]=1)[C:33](O)=[O:34].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)C(C)C)C>CN(C=O)C.C1COCC1>[CH2:21]([N:13]([CH3:14])[C:6]1[C:7]2[S:11][C:10]([NH:12][C:33](=[O:34])[C:32]3[CH:36]=[CH:37][N:38]=[C:30]([Br:29])[CH:31]=3)=[N:9][C:8]=2[C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1참가 물질
9
반응물 6
HCID 7498Benzyl Bromide
HCID 11430Potassium Carbonate
HCID 81531Diisopropylethylamine
HCID 2227012-Bromoisonicotinic acid
HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)
HCID 227369784-methoxy-N7-methyl-benzothiazole-2,7-diamine생성물 1
시약·촉매·용매 2
실험 절차
From 4-methoxy-N7-methyl-benzothiazole-2,7-diamine with potassium carbonate and benzyl bromide in DMF, then treatment with 2-bromo-isonicotinic acid, HATU and N-ethyldiisopropylamine in THF. ES-MS m/e (%): 485 (M{81Br}+H+, 98), 483 (M{79Br}+H+, 100).
출처 및 근거
- ORD 기록
- ord-766d40b0b1ba4d8f86b8993316cf8687
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06713499B2
연결된 노트
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