HCID 610084, 화합물 → Methyl 3-phenyl-1-adamantaneacetate

HRID 51983

반응식

HRID 51983 반응식
Br[C:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][C:4]([CH2:12][C:13]([O:15][CH3:16])=[O:14])([CH2:5]3)[CH2:3]1)[CH2:9]2.[Cl-].[Cl-].[Cl-].[Al+3]>C1C=CC=CC=1>[C:2]1([C:2]23[CH2:11][CH:6]4[CH2:7][CH:8]([CH2:10][C:4]([CH2:12][C:13]([O:15][CH3:16])=[O:14])([CH2:5]4)[CH2:3]2)[CH2:9]3)[CH:11]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 610084HCID 610084, 화합물HCID 6451240Aluminum(III) Chloride

생성물 1

HCID 53665692Methyl 3-phenyl-1-adamantaneacetate수율 202%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

Methyl 3-bromoadamantaneacetate (80 g) (Aldrich Chemical Co. Milwaukee Wis.) was dissolved in benzene (1.6 L) under nitrogen. Aluminum trichloride (37.12 g) was added portionwise over 75 min. at ambient temperature. The reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L). The layers were separated and the organic layer was dried over sodium sulfate, filtered, and evaporated in vacuo to give methyl 3-phenyl-1-adamantaneacetate (80 g).

후처리

  1. customThe reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L)
  2. customThe layers were separated
  3. dry with materialthe organic layer was dried over sodium sulfate
  4. filtrationfiltered
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-33797f736a214462ba6cf92a008f2560
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05616505

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