Hydrochloric Acid → Methyl 2-amino-3-(pyrazine-2-carboxamido)benzoate

HRID 520446노트

반응식

HRID 520446 반응식
Cl.C(OC([N:9](C(OC(C)(C)C)=O)[C:10]1[C:19]([NH:20][C:21]([C:23]2[CH:28]=[N:27][CH:26]=[CH:25][N:24]=2)=[O:22])=[CH:18][CH:17]=[CH:16][C:11]=1[C:12]([O:14][CH3:15])=[O:13])=O)(C)(C)C>CO>[NH2:9][C:10]1[C:19]([NH:20][C:21]([C:23]2[CH:28]=[N:27][CH:26]=[CH:25][N:24]=2)=[O:22])=[CH:18][CH:17]=[CH:16][C:11]=1[C:12]([O:14][CH3:15])=[O:13]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 58552825Methyl 2-(bis-(tert-butoxycarbonyl)amino)-3-(pyrazine-2-carboxamido)benzoate

생성물 1

HCID 58552889Methyl 2-amino-3-(pyrazine-2-carboxamido)benzoate수율 85.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

HCl gas was bubbled through a solution of methyl 2-(bis-(tert-butoxycarbonyl)amino)-3-(pyrazine-2-carboxamido)benzoate 14 (2.8 g, 5.9 mmol) in MeOH (50 ml) for 2 h. The volatiles were removed in vacuo and H2O (20 mL) was added. The pH was adjusted to 7 using aq NaOH and the resulting precipitate was collected by filtration, rinsed with H2O, and dried under vacuum to give 15 (1.37 g, 85% yield).

후처리

  1. customThe volatiles were removed in vacuo and H2O (20 mL)
  2. additionwas added
  3. filtrationthe resulting precipitate was collected by filtration
  4. washrinsed with H2O
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-ae83657fa39745ff91cb120e5eb5db9e
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09326986B2

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