Acetic Anhydride → 8-Nitro-2-(3-(trifluoromethyl)phenyl)quinolin-4-yl acetate

HRID 520461노트

반응식

HRID 520461 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[NH:12][C:11]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=1)=[CH:10][C:9]2=[O:24])([O-:3])=[O:2].C(N(CC)CC)C.[CH3:32][C:33](OC(C)=O)=[O:34].C([O-])(O)=O.[Na+]>C(Cl)Cl>[C:33]([O:24][C:9]1[C:8]2[C:13](=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[CH:6][CH:7]=2)[N:12]=[C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:21])[F:22])[CH:15]=2)[CH:10]=1)(=[O:34])[CH3:32]

참가 물질

6

반응물 4

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 516892Sodium BicarbonateHCID 585529228-nitro-2-(3-(trifluoromethyl)phenyl)quinolin-4(1H)-one

생성물 1

HCID 585528568-Nitro-2-(3-(trifluoromethyl)phenyl)quinolin-4-yl acetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 8-nitro-2-(3-(trifluoromethyl)phenyl)quinolin-4(1H)-one 37 (707 mg, 2.11 mmol), triethylamine (1 mL), and Ac2O (0.7 mL) in CH2Cl2 (10 mL) was stirred at room temperature for 16 h. Sat. aq NaHCO3 (10 mL) was added, and the reaction extracted with CH2Cl2. The combined organic layers were dried (MgSO4) and concentrated to give 38.

후처리

  1. extractionthe reaction extracted with CH2Cl2
  2. dry with materialThe combined organic layers were dried (MgSO4)
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a2d89c3bf66c4a74b48425fa29bee2a5
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09326986B2

반응 노트

불러오는 중…