Acetic Anhydride → Acetic acid 3-(2-hydroxy-ethyl)-phenyl ester

HRID 521511

반응식

HRID 521511 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][OH:10])[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])O.[Na+].[C:16](OC(=O)C)(=[O:18])[CH3:17]>O1CCOCC1.O>[OH:10][CH2:9][CH2:8][C:4]1[CH:3]=[C:2]([O:1][C:16](=[O:18])[CH3:17])[CH:7]=[CH:6][CH:5]=1

참가 물질

6

반응물 3

HCID 7918Acetic AnhydrideHCID 834043-Hydroxyphenethyl alcoholHCID 516892Sodium Bicarbonate

생성물 1

HCID 67076782Acetic acid 3-(2-hydroxy-ethyl)-phenyl ester

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

2-(3-Hydroxyphenyl)ethanol (400 mg, 2.90 mmol) was dissolved in a mixture of 4 ml of dioxane and 4 ml of water, and sodium hydrogencarbonate (2.43 g, 29 mmol) was added followed by acetic anhydride (2.96 g, 29 mmol) with ice cooling. The mixture was stirred overnight at room temperature and then partitioned between 2 N hydrochloric acid and EA. The aqueous phase was extracted with EA, the combined organic phases were dried over sodium sulfate and evaporated to dryness to yield the crude title compound which was used without further purification.

후처리

  1. additionwas added
  2. custompartitioned between 2 N hydrochloric acid and EA
  3. extractionThe aqueous phase was extracted with EA
  4. dry with materialthe combined organic phases were dried over sodium sulfate
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-1eee8947a8e040e8a10209160bf2a857
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09328071B2

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