Methanol → HCID 67076690, 화합물

HRID 521531노트

반응식

HRID 521531 반응식
[CH3:1][O:2][C:3]([C:5]1([NH:14][C:15](=[O:26])[C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([CH:24]=[O:25])[CH:17]=2)[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6]1)=[O:4].[BH4-].[Na+].CO>C1COCC1>[CH3:1][O:2][C:3]([C:5]1([NH:14][C:15](=[O:26])[C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([CH2:24][OH:25])[CH:17]=2)[CH2:6][C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:13]1)=[O:4]

참가 물질

5

반응물 3

HCID 887MethanolHCID 4311764Sodium borohydrideHCID 86654801HCID 86654801, 화합물

생성물 1

HCID 67076690HCID 67076690, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The compound of step 1 (0.500 g, 1.42 mmol) was dissolved in THF (5 ml) and cooled in an ice bath. Sodium borohydride (0.164 g, 4.25 mmol) was added. Subsequently methanol (2 ml) was added dropwise. After 1 h, the volatiles were evaporated, the residue was partitioned between diethyl ether and a saturated sodium hydrogencarbonate solution, and the aqueous phase extracted with diethyl ether. The combined organic phases were dried over sodium sulfate and evaporated to dryness.

후처리

  1. temperaturecooled in an ice bath
  2. customthe volatiles were evaporated
  3. customthe residue was partitioned between diethyl ether
  4. extractiona saturated sodium hydrogencarbonate solution, and the aqueous phase extracted with diethyl ether
  5. dry with materialThe combined organic phases were dried over sodium sulfate
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-f3658bbb1cb5434194eaa597baec6c90
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09328071B2

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