Hydrochloric Acid → N-[4-(2-Amino-ethoxy)-3-(2-methyl-2H-pyrazol-3-yl)-phenyl]-2-oxo-2-p-tolyl-acetamide

The 2-oxo-2-p-tolylacetic acid (14.82 mg, 1.2 eq),), triethylamine (31.45 μL, 3.0 eq) and HATU (34.32 mg, 1.2 eq) were dissolved in 1 mL of dichloromethane and stirred at room temperature for 20 minutes. At this time tert-butyl 2-(4-amino-2-(1-methyl-1H-pyrazol-5-yl)phenoxy)ethylcarbamate (25.0 mg, 75.2 μmol) dissolved in 0.5 mL of dichloromethane was added and the reaction was stirred at room temperature for 18 hr. The solvent was evaporated under a stream of nitrogen and the residue was dissolved in 0.5 mL of ethyl acetate. To this was added 2.0M hydrochloric acid in ether (188 μL, 5 eq) and the reaction was stirred at room temperature overnight. The solvent was evaporated under a stream of nitrogen and the residue was dissolved in 1 mL of dimethylsulfoxide and purified by HPLC. The proper fractions were collected and lyophilized to afford the title compound as a white solid in 32.2% yield. LCMS m/z (%)=379 (M+H, 100. 1H NMR (400 MHz, DMSO-d6) δ ppm 2.42 (s, 3H), 3.12-3.21 (m, 2H), 3.71 (s, 3H), 4.19 (t, J=5.56 Hz, 2H), 6.37 (d, J=1.52 Hz, 1H), 7.26 (d, J=9.09 Hz, 1H), 7.42 (d, J=8.59 Hz, 2H), 7.49 (d, J=2.02 Hz, 1H), 7.70 (d, J=2.53 Hz, 1H), 7.82 (dd, J=9.09, 2.53 Hz, 1H), 7.97 (d, J=8.08 Hz, 2H), 10.96 (s, 1H).

1. additionwas added
2. stirringthe reaction was stirred at room temperature for 18 hr
3. customThe solvent was evaporated under a stream of nitrogen
4. dissolutionthe residue was dissolved in 0.5 mL of ethyl acetate
5. stirringthe reaction was stirred at room temperature overnight
6. customThe solvent was evaporated under a stream of nitrogen
7. dissolutionthe residue was dissolved in 1 mL of dimethylsulfoxide
8. custompurified by HPLC
9. customThe proper fractions were collected

ORD 기록

ord-99da7568873c4324a272726444a71527

출처 데이터셋

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US09328107B2