4-Chlorobenzyl alcohol → 1-(Bromomethyl)-4-chlorobenzene

HRID 52181

반응식

HRID 52181 반응식
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]O)=[CH:4][CH:3]=1.P(Br)(Br)[Br:11]>C(Cl)Cl>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][Br:11])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 133974-Chlorobenzyl alcoholHCID 24614Phosphorus tribromide

생성물 1

HCID 693291-(Bromomethyl)-4-chlorobenzene

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a suspension of 4-chlorobenzyl alcohol (14.26 g, 100 mmol) in CH2Cl2 (40 mL) at ambient temperature was added added dropwise a solution of PBr3 in CH2Cl2 (1.0M, 32 mL, 32 mmol). The reaction mixture was stirred for 72 hours at ambient temperature and then was poured slowly onto ice. The layers were separated and the organic phase was dried over MgSO4, filtered, and concentrated in vacuo to give 4-chlorobenzyl bromide (19.76 g) as a colorless solid.

후처리

  1. additionwas added
  2. additionwas poured slowly onto ice
  3. customThe layers were separated
  4. dry with materialthe organic phase was dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-b84de76bff364798be1a6cb094b81efd
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05616596

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