N-Iodosuccinimide → 2-Iodo-3-(4fluorophenylmethyl)thiophene

HRID 52188노트

반응식

HRID 52188 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]2[CH:13]=[CH:12][S:11][CH:10]=2)=[CH:4][CH:3]=1.C(Cl)(Cl)Cl.CO.[I:20]N1C(=O)CCC1=O>C(Cl)Cl>[I:20][C:10]1[S:11][CH:12]=[CH:13][C:9]=1[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1

참가 물질

5

반응물 3

HCID 120273N-IodosuccinimideHCID 199633023-(4-Fluorophenylmethyl)thiopheneHCID 21584188Chloroform methanol

생성물 1

HCID 199632792-Iodo-3-(4fluorophenylmethyl)thiophene수율 95.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 3-(4-fluorophenylmethyl)thiophene (1.16 g, 6.04 mmol) in 1:1 CHCl3 /methanol was added N-iodosuccinimide (1.70 g, 7.53 mmol). The reaction mixture was stirred for 3 hours, and then was diluted with CH2Cl2. The organic phase was extracted with saturated aqueous NaHCO3 and brine, dried over MgSO4, filtered, and concentrated in vacuo to give 1.83 g of 2-iodo-3-(4fluorophenylmethyl)thiophene which was used without further purification.

후처리

  1. extractionThe organic phase was extracted with saturated aqueous NaHCO3 and brine
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-76414163d6a84d8b834fadd2b1086ec7
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05616596

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