Ammonium Hydroxide → Thiophen-2-acetamide

HRID 52190

반응식

HRID 52190 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7](Cl)=[O:8].[NH4+:10].[OH-]>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH2:10])=[O:8]

참가 물질

3

반응물 2

HCID 14923Ammonium HydroxideHCID 1623622-Thiopheneacetyl chloride

생성물 1

HCID 78208Thiophen-2-acetamide수율 64%

실험 절차

To a mixture of concentrated NH4OH (100 mL) and ice was added 2-thiopheneacetyl chloride (13.0 g, 80.9 mmol). The desired compound crystallized from the reaction mixture. Recrystallization from hot water gave 2-thiopheneacetamide (8.08 g, 64% yield) as white crystals. mp 146°-147° C.

후처리

  1. customThe desired compound crystallized from the reaction mixture
  2. customRecrystallization from hot water

출처 및 근거

ORD 기록
ord-d50cdad937b642df885f4e3877aa82ac
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05616596

연결된 노트

불러오는 중…