Sodium Hydroxide → 4-Methyl-3-oxopentanoic acid

HRID 522241노트

반응식

HRID 522241 반응식
[OH-].[Na+].[C:3]([CH2:8][C:9]([O:11]C)=[O:10])(=[O:7])[CH:4]([CH3:6])[CH3:5]>O>[C:3]([CH2:8][C:9]([OH:11])=[O:10])(=[O:7])[CH:4]([CH3:6])[CH3:5]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 2759969Methyl 4-methyl-3-oxopentanoate

생성물 1

HCID 4400244-Methyl-3-oxopentanoic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Sodium hydroxide (0.4 g) was dissolved in water (10 ml) and methyl isobutyrylacetate (manufactured by Fluka Corp., 1.44 g) was added thereto and stirred for 6 hours at room temperature. The reaction product was washed with ether and ether extraction was performed by adding a 10%-dilute sulfuric acid (4.9 g). An excess of anhydrous sodium sulfate was added to the ether extract, drying was performed thereon, and the anhydrous sodium sulfate was removed by filtering. In addition, the ether was removed using a rotary evaporator and an isobutyrylacetic acid was obtained (yield: 1 g).

후처리

  1. washThe reaction product was washed with ether and ether extraction
  2. additionby adding a 10%-dilute sulfuric acid (4.9 g)
  3. additionAn excess of anhydrous sodium sulfate was added to the ether
  4. extractionextract
  5. customdrying
  6. customthe anhydrous sodium sulfate was removed
  7. filtrationby filtering
  8. customIn addition, the ether was removed
  9. customa rotary evaporator

출처 및 근거

ORD 기록
ord-ce490a7ad0dc4313add3ca603492e57b
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09328254B2

반응 노트

불러오는 중…