4-Aminostyrene → 1-(4-Vinylphenyl)-3-[3,5-bis(trifluoromethyl)phenyl]thiourea

HRID 522337

반응식

HRID 522337 반응식
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[CH2:7])=[CH:4][CH:3]=1.[F:10][C:11]([F:26])([F:25])[C:12]1[CH:13]=[C:14]([N:22]=[C:23]=[S:24])[CH:15]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:17]=1>C1COCC1>[CH:6]([C:5]1[CH:8]=[CH:9][C:2]([NH:1][C:23]([NH:22][C:14]2[CH:15]=[C:16]([C:18]([F:19])([F:20])[F:21])[CH:17]=[C:12]([C:11]([F:10])([F:25])[F:26])[CH:13]=2)=[S:24])=[CH:3][CH:4]=1)=[CH2:7]

참가 물질

4

반응물 2

HCID 737004-AminostyreneHCID 27333953,5-Bis(trifluoromethyl)phenyl isothiocyanate

생성물 1

HCID 581124441-(4-Vinylphenyl)-3-[3,5-bis(trifluoromethyl)phenyl]thiourea수율 60%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of 4-aminostyrene (3.5 mmol) in dry THF (20 mL) under nitrogen was added 3,5-bis-(trifluoromethyl)phenyl isothiocyanate (3.5 mmol). The solution was refluxed overnight and then the solvent was evaporated under reduced pressure. The resulting solid residue was purified by column chromatography to yield the desired product in 60% yield.

후처리

  1. temperatureThe solution was refluxed overnight
  2. customthe solvent was evaporated under reduced pressure
  3. customThe resulting solid residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-3fe51d0a917048c28d43fc50b0e7264a
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09329186B2

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