Morpholine → 4-[4,6-Bis(trichloromethyl)-1,3,5-triazin-2-yl]morpholine

HRID 522519노트

반응식

HRID 522519 반응식
Cl[C:2]1[N:7]=[C:6]([C:8]([Cl:11])([Cl:10])[Cl:9])[N:5]=[C:4]([C:12]([Cl:15])([Cl:14])[Cl:13])[N:3]=1.[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1.C(N(CC)C(C)C)(C)C>C1COCC1>[Cl:13][C:12]([Cl:15])([Cl:14])[C:4]1[N:5]=[C:6]([C:8]([Cl:11])([Cl:10])[Cl:9])[N:7]=[C:2]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)[N:3]=1

참가 물질

5

반응물 3

HCID 8083MorpholineHCID 35663HCID 35663, 화합물HCID 81531Diisopropylethylamine

생성물 1

HCID 326384-[4,6-Bis(trichloromethyl)-1,3,5-triazin-2-yl]morpholine수율 44.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Dissolved 2-chloro-4,6-bis(trichloromethyl)-1,3,5-triazine (0.1 g, 0.28 mmol) in THF (1.5 mL). Added morpholine (0.24 mL, 0.29 mmol) and N,N-diisopropylethylamine (0.06 mL, 0.34 mmol) and stirred for 18 h at room temperature. Concentrated and purified by silica gel chromatography eluting with CH2Cl2 to obtain the title compound (0.05 g).

후처리

  1. concentrationConcentrated
  2. custompurified by silica gel chromatography
  3. washeluting with CH2Cl2

출처 및 근거

ORD 기록
ord-7df5bca0fcda493393b2a4d2c0242e40
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09334246B2

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