4-bromo-1-methyl-1H-pyrazole-5-carbaldehyde → (4-bromo-1-methyl-1H-pyrazol-5-yl)methanol

HRID 523107

반응식

HRID 523107 반응식
[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH3:9])[C:6]=1[CH:7]=[O:8].[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH3:9])[C:6]=1[CH2:7][OH:8]

참가 물질

4

반응물 2

HCID 27946344-bromo-1-methyl-1H-pyrazole-5-carbaldehydeHCID 4311764Sodium borohydride

생성물 1

HCID 57415773(4-bromo-1-methyl-1H-pyrazol-5-yl)methanol수율 90%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 4-bromo-1-methyl-1H-pyrazole-5-carbaldehyde (677 mg, 3.58 mmol) in MeOH (8 mL) at 0° C., NaBH4 (136 mg, 0.86 mmol) was added. The solution was stirred at room temperature for 2 hours. The reaction was concentrated in vacuo and diluted with water. The solution was extracted with EtOAc, the organic layer collected, dried over sodium sulphate and concentrated in vacuo to afford the title compound as a white solid (614 mg, 90%).

후처리

  1. concentrationThe reaction was concentrated in vacuo
  2. additiondiluted with water
  3. extractionThe solution was extracted with EtOAc
  4. customthe organic layer collected
  5. dry with materialdried over sodium sulphate
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-292f601f3fab4682ac53935aab33a93b
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09334286B2

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