Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → 4-bromo-5-(methoxymethyl)-1-methyl-1H-pyrazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | (4-bromo-1-methyl-1H-pyrazol-5-yl)methanol | HCID 57415773 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | tetrahydrofuran N,N-dimethylformamide | HCID 21974620 | — |
| 용매 | Sodium chloride; water | HCID 57417360 | — |
| 생성물 | 4-bromo-5-(methoxymethyl)-1-methyl-1H-pyrazole | HCID 89995604 | 67.2% |
반응 단계
NaH (60%, 58 mg) was added to a solution of (4-bromo-1-methyl-1H-pyrazol-5-yl)methanol (Preparation 149, 97 mg, 1.03 mmol) in THF/DMF (8/4 mL). After stirring for 15 minutes, iodomethane (439 mg, 3.09 mmol) in THF (1 mL) was added. The resulting solution was stirred at room temperature for 16 hours. The reaction mixture was diluted with brine and extracted with EtOAc. The combined organic layers were washed with water, dried over sodium sulphate and concentrated in vacuo to afford the title compound (142 mg, 67%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09334286B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-07e36eea7b7d45ccb68517445ea40eec |
| 출처 메모 | uspto-grants-2016_05 |