反应详情

NaH (60%, 58 mg) was added to a solution of (4-bromo-1-methyl-1H-pyrazol-5-yl)methanol (Preparation 149, 97 mg, 1.03 mmol) in THF/DMF (8/4 mL). After stirring for 15 minutes, iodomethane (439 mg, 3.09 mmol) in THF (1 mL) was added. The resulting solution was stirred at room temperature for 16 hours. The reaction mixture was diluted with brine and extracted with EtOAc. The combined organic layers were washed with water, dried over sodium sulphate and concentrated in vacuo to afford the title compound (142 mg, 67%).

1. stirringThe resulting solution was stirred at room temperature for 16 hours
2. extractionextracted with EtOAc
3. washThe combined organic layers were washed with water
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated in vacuo