Potassium Carbonate → 3-Bromo-2-(cyclopropylmethoxy)benzaldehyde

HRID 523995노트

반응식

HRID 523995 반응식
[Br:1][C:2]1[C:9]([OH:10])=[CH:8][CH:7]=[CH:6][C:3]=1C=O.Br[CH2:12][CH:13]1[CH2:15][CH2:14]1.[C:16]([O-:19])([O-])=O.[K+].[K+]>CN(C=O)C.O>[Br:1][C:2]1[CH:3]=[CH:6][CH:7]=[C:8]([C:16]=1[O:19][CH2:12][CH:13]1[CH2:15][CH2:14]1)[CH:9]=[O:10]

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 81503BromomethylcyclopropaneHCID 37146742-Bromo-3-hydroxybenzaldehyde

생성물 1

HCID 597250443-Bromo-2-(cyclopropylmethoxy)benzaldehyde

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

300 mg (1.49 mmol) 2-Bromo-3-hydroxy-benzaldehyde, 302 mg (2.24 mmol) (bromomethyl)cyclopropane and 412 mg (2.99 mmol) K2CO3 in 3 mL DMF are stirred at 80° C. over night. Afterwards the reaction mixture is diluted with water and extracted with EtOAc. The organic layer is separated and dried over Na2SO4, filtered and the solvent is removed in vacuo.

후처리

  1. extractionextracted with EtOAc
  2. customThe organic layer is separated
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. customthe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-1ee4c086c6534256b2b3745d812ea9f3
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09340510B2

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