Cysteamine → Ethyl thiomorpholine-3-carboxylate
반응식
[NH2:1][CH2:2][CH2:3][SH:4].C(N(CC)CC)C.Br[CH:13]([CH2:19]Br)[C:14]([O:16][CH2:17][CH3:18])=[O:15].C(Cl)(Cl)Cl.C1(C)C=CC=CC=1>C(Cl)(Cl)Cl>[NH:1]1[CH2:2][CH2:3][S:4][CH2:19][CH:13]1[C:14]([O:16][CH2:17][CH3:18])=[O:15]참가 물질
6
실험 절차
A warm solution of 2-aminoethanethiol (10.0 g, 0.130 mol) and triethylamine (36 mL, 0.260 mol) in chloroform is added over 5 minutes to a solution of ethyl 2,3-dibromopropionate (33.9 g, 0.130 mol) in a chloroform/toluene (1:1.6) solution. The reaction mixture is stirred at room temperature for 2.5 hours, filtered and concentrated in vacuo to obtain an orange liquid. The liquid is vacuum distilled to give the title product as a colorless liquid, bp 121°-124° C. at 3 mm Hg.
후처리
- filtrationfiltered
- concentrationconcentrated in vacuo
- customto obtain an orange liquid
- distillationdistilled
출처 및 근거
- ORD 기록
- ord-b7d20cb49fd94e2f989a2a4aba6d15b5
- 출처 데이터셋
- uspto-grants-1997_04
- 특허 번호
- US05616706
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