Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromine → (S)-5-Bromo-1-sec-butyl-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid (5-methanesulfonyl-pyridin-2-ylmethyl)-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | 4-Methylsulfonylbenzylamine hydrochloride | HCID 2729269 | — |
| 반응물 | (5-(Methylsulfonyl)pyridin-2-yl)methanamine | HCID 57354332 | — |
| 반응물 | 5-Bromo-1-isopropyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid | HCID 86711577 | — |
| 반응물 | (S)-5-Bromo-1-sec-butyl-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid | HCID 86711586 | — |
| 생성물 | (S)-5-Bromo-1-sec-butyl-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid (5-methanesulfonyl-pyridin-2-ylmethyl)-amide | HCID 86711585 | — |
반응 단계
Preparation 20 is prepared following the procedure for preparation 5, substituting preparation 3c with preparation 12b and 4-methylsulfonylbenzylamine hydrochloride with C-(5-methanesulfonyl-pyridin-2-yl)-methylamine. ESI mass spectrum: [M+H]+=456 (bromine isotope pattern); Retention time HPLC: 0.87 min (Z018_S04).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09340507B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-e29899bc0b0a4cabb94a3ac740daba2d |
| 출처 메모 | uspto-grants-2016_05 |