Acetic Anhydride → N-acetyl-2-furfurylthioacetamide

HRID 52436노트

반응식

HRID 52436 반응식
[CH2:1]([CH2:7][C:8]([NH2:10])=[S:9])[C:2]1[O:6][CH:5]=[CH:4][CH:3]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12].C(OCC)(=O)C>N1C=CC=CC=1>[C:11]([NH:10][C:8](=[S:9])[CH2:7][CH2:1][C:2]1[O:6][CH:5]=[CH:4][CH:3]=1)(=[O:13])[CH3:12]

참가 물질

5

반응물 3

HCID 7918Acetic AnhydrideHCID 8857Ethyl AcetateHCID 199636792-Furfurylthioacetamide

생성물 1

HCID 19963689N-acetyl-2-furfurylthioacetamide

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
80 °C

실험 절차

8.56 g (0.05 mol) of 2-furfurylthioacetamide, 5.61 g (0.055 mol) of acetic anhydride, and 6.11 g (0.05 mol) of N,N-dimethyl-aminopyridine were dissolved in 50 ml of pyridine. The mixture was stirred at 80° C. for 16 hours. The solvent was distilled away from the reaction mixture, and the residue thus obtained was added to ethyl acetate and washed successively with water, 1N hydrochloric acid, water three times, and brine. A resultant organic extract layer was dried, and the solvent was distilled away therefrom, so that N-acetyl-2-furfurylthioacetamide was obtained in a yield of 7.11 g (60%).

후처리

  1. distillationThe solvent was distilled away from the reaction mixture
  2. customthe residue thus obtained
  3. washwashed successively with water, 1N hydrochloric acid, water three times, and brine
  4. customA resultant organic extract layer was dried
  5. distillationthe solvent was distilled away

출처 및 근거

ORD 기록
ord-76330c2324714914941aad18f42a0b71
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05616711

반응 노트

불러오는 중…