N-bromobutanimide → Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(1-(2-ethoxy-2-oxoethyl)-1H-1,2,4-triazol-3-yl)-1,4-dihydropyrimidine-5-carboxylate

HRID 524710노트

반응식

[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:13]([CH3:20])[NH:12][C:11]([C:21]2[N:25]=[CH:24][N:23]([CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28])[N:22]=2)=[N:10]1.C1C(=O)N([Br:39])C(=O)C1>>[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:13]([CH2:20][Br:39])[NH:12][C:11]([C:21]2[N:25]=[CH:24][N:23]([CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28])[N:22]=2)=[N:10]1

참가 물질

반응물 2

HCID 67184N-bromobutanimide

HCID 90043601Ethyl 4-(2-bromo-4-fluorophenyl)-2-(1-(2-ethoxy-2-oxoethyl)-1H-1,2,4-triazol-3-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate

생성물 1

HCID 118107556Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(1-(2-ethoxy-2-oxoethyl)-1H-1,2,4-triazol-3-yl)-1,4-dihydropyrimidine-5-carboxylate수율 69%

실험 절차

Ethyl 4-(2-bromo-4-fluorophenyl)-2-(1-(2-ethoxy-2-oxoethyl)-1H-1,2,4-triazol-3-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate (0.45 g, 0.91 mmol) was reacted with NBS (0.16 g, 0.91 mmol) according to the procedure as described in Example 1, Step B to give the title compound as a yellow solid (0.36 g, 69%). The compound was characterized by the following spectroscopic data:

출처 및 근거

ORD 기록: ord-7e27f6c8e4074536bf8de9be44667784
출처 데이터셋: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09340538B2

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