Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chlorobenzylamine → (S)-tert-Butyl 1-(3-bromo-2-(2-chlorobenzylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chlorobenzylamine | HCID 66648 | — |
| 반응물 | (S)-Methyl 3-bromo-1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate | HCID 86722018 | — |
| 생성물 | (S)-tert-Butyl 1-(3-bromo-2-(2-chlorobenzylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate | HCID 86722048 | 65% |
반응 단계
The title compound was prepared from (S)-Methyl 3-bromo-1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate (310 mg, 0.8 mmol) and (2-chlorophenyl)methanamine (385 μL, 3.2 mmol) following the experimental procedure described in Preparation 44a. 259 mg (65% yield) of the desired compound were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09340547B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-f4767860006d4c1aa19e5a4d7d507dc3 |
| 출처 메모 | uspto-grants-2016_05 |