Hydrochloric Acid → trans-3-Amino-4-methoxypyrrolidine dihydrochloride

HRID 525757노트

반응식

[ClH:1].[NH2:2][C@H:3]1[C@H:7]([O:8][CH3:9])[CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.Cl.CCO>>[ClH:1].[ClH:1].[CH3:9][O:8][C@@H:7]1[CH2:6][NH:5][CH2:4][C@H:3]1[NH2:2]

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 89906581rac-tert-butyl (3R,4R)-3-amino-4-methoxypyrrolidine-1-carboxylate hydrochloride

생성물 1

HCID 67925434trans-3-Amino-4-methoxypyrrolidine dihydrochloride

실험 절차

A mixture of (trans)-tert-butyl 3-amino-4-methoxypyrrolidine-1-carboxylate hydrochloride (0.5 g, 1.939 mmol) and HCl in EtOH (15.51 mL, 19.39 mmol) was stirred at RT for 24 h. The solvent was evaporated off under reduced pressure to give the title compound.

후처리

customThe solvent was evaporated off under reduced pressure

출처 및 근거

ORD 기록: ord-84f24c5cc7c54af8a3e6cfe8c58b6d4e
출처 데이터셋: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09340537B2

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