Valproic Acid → (R)-N5-[Amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl]-N2-(1-oxo-2-propylpentyl)-ornithinamide

HRID 52591

반응식

HRID 52591 반응식
[NH2:1][C:2](=[N:20][N+:21]([O-:23])=[O:22])[NH:3][CH2:4][CH2:5][CH2:6][C@H:7]([C:9]([NH:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1)=[O:10])[NH2:8].[CH2:24]([CH:27]([CH2:31][CH2:32][CH3:33])[C:28](O)=[O:29])[CH2:25][CH3:26].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>O1CCCC1>[NH2:1][C:2](=[N:20][N+:21]([O-:23])=[O:22])[NH:3][CH2:4][CH2:5][CH2:6][C@H:7]([C:9]([NH:11][CH2:12][C:13]1[CH:14]=[CH:15][C:16]([OH:19])=[CH:17][CH:18]=1)=[O:10])[NH:8][C:28](=[O:29])[CH:27]([CH2:31][CH2:32][CH3:33])[CH2:24][CH2:25][CH3:26]

참가 물질

5

반응물 3

HCID 3121Valproic AcidHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 136381090(R)-N5-[amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl)-ornithinamide

생성물 1

HCID 136381110(R)-N5-[Amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl]-N2-(1-oxo-2-propylpentyl)-ornithinamide수율 65%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Prepared analogously to Example 5d), but using tetrahydrofuran instead of acetonitrile, from (R)-N5 -[amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl]-ornithinamide, 2-propyl-pentanoic acid and TBTU in a yield of 65% of theory. Colourless crystalline substance which was further processed without purification.

후처리

  1. customPrepared analogously to Example 5d), but
  2. customColourless crystalline substance which was further processed without purification

출처 및 근거

ORD 기록
ord-6015da7a28fd4a88b0e39061f1a3dbc5
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05616620

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