5,5-Diphenylhydantoin → 3-[(3-Cyanophenyl)methyl]-4,5-dihydro-5,5-diphenyl-1H-imidazol-2,4(3H)-dione

HRID 52593

반응식

HRID 52593 반응식
[C:1]1([C:7]2([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[NH:11][C:10](=[O:12])[NH:9][C:8]2=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[C:25]#[N:26].CC(C)([O-])C.[K+]>CN(C)C=O>[C:25]([C:24]1[CH:23]=[C:22]([CH2:21][N:9]2[C:8](=[O:13])[C:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[NH:11][C:10]2=[O:12])[CH:29]=[CH:28][CH:27]=1)#[N:26]

참가 물질

5

반응물 3

HCID 17755,5-DiphenylhydantoinHCID 97249Benzonitrile, 3-(bromomethyl)-HCID 23665647Potassium tert-butoxide

생성물 1

HCID 189759213-[(3-Cyanophenyl)methyl]-4,5-dihydro-5,5-diphenyl-1H-imidazol-2,4(3H)-dione

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Prepared by reacting 25.5 g (0.101 Mol) of 5,5-diphenylhydantoin with 21.15 g (0.108 Mol) of 3-(bromomethyl)-benzonitrile in the presence of 12.0 g (0.107 Mol) of potassium tert.-butoxide and 200 ml of anhydrous dimethylformamide. After conventional working up 34.0 g (92% of theory) of colourless crystals were obtained, mp. 160°-164° C.

후처리

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출처 및 근거

ORD 기록
ord-2c4e7f36e9c3472cb708dcb2ea44cdc0
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05616620

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